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Vurderingen tager udover risikoen for forgiftning blandt andet også udgangspunkt i "stoffets afhængighedsskabende potentiale" og "risiko for anden sygdom eller skadevirkning som følge af brug af stoffet".Male starter oftest den smertestillende behandling med et svagt virkende middel, hvis ikke smerterne allerede er blevet stærke.Tapentadol (Pal